If signs and symptoms of tardive dyskinesia appear in a patient on antipsychotics, drug discontinuation should be considered. Nursing Mothers There is evidence that chlorpromazine is excreted in the breast milk of nursing mothers. Reproductive studies in rodents have demonstrated potential for embryotoxicity, increased neonatal mortality and nursing transfer of the drug.
If tests indicate an abnormality, stop treatment.
Drug Status Rx. Rare instances of skin pigmentation have been observed in hospitalized mental patients, primarily females who have received the drug usually for 3 years or more in dosages ranging from 500 mg to 1500 mg daily.
Applies to the following strengths: Allergic Reactions of a mild urticarial type or photosensitivity are seen. As with other phenothiazine derivatives, chlorpromazine should be discontinued at least 48 hours before myelography, should not be resumed for at least 24 hours postprocedure, and should not be used for the control of nausea and vomiting occurring either prior to myelography or postprocedure with metrizamide.
Chlorpromazine diminishes the effect of oral anticoagulants. Chlorpromazine prolongs and intensifies the action of CNS depressants such as anesthetics, barbiturates and narcotics. Chlorpromazine Dosage Medically reviewed on October 22, 2018.
Should it be necessary to reinstitute treatment, or increase the dosage of the agent, or switch to a different antipsychotic agent, the syndrome may be masked. If necessary, give additional 25 to 50 mg injection in 1 hour. Dosage and frequency of administration should be adjusted according to the severity of the symptoms and response of the patient. Treatment with anti-parkinsonian agents, benzodiazepines or propranolol may be helpful.
Chlorpromazine has strong antiadrenergic and weaker peripheral anticholinergic activity; ganglionic blocking action is relatively slight. These symptoms can usually be avoided or reduced by gradual reduction of the dosage or by continuing concomitant anti-parkinsonism agents for several weeks after chlorpromazine is withdrawn.
When chlorpromazine is used with cancer chemotherapeutic drugs, vomiting as a sign of the toxicity of these agents may be obscured by the antiemetic effects of chlorpromazine. Hypotension and extrapyramidal symptoms. The extrapyramidal symptoms which can occur secondary to chlorpromazine may be confused with the central nervous system signs of an undiagnosed primary disease responsible for the vomiting, e.
Slight yellowing will not alter potency. Chlorpromazine Hydrochloride Injection contains sodium metabisulfite and sodium sulfite, sulfites that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people.
Reports suggest that the eye lesions may regress after withdrawal of the drug. Dosage should not be increased until these side effects have subsided. Hyperglycemia, hypoglycemia and glycosuria have been reported.
They are discussed in the following paragraphs:.